工作经历：
2024.12 至今 南京大学医学院 准聘副教授
2021.01 – 2024.12 宾夕法尼亚大学（UPenn）博士后研究员 （合作导师：Michael J. Mitchell教授）

教育背景：
2016.10 – 2020.11 萨尔大学（德国）化学博士 （导师：崔家喜/Arancha del Campo教授）
2013.09 – 2016.07 苏州大学 工学硕士 （导师：陈红教授）
2009.09 – 2013.07 青岛科技大学 工学学士

科研方向：
1） 多尺度生物材料制备
2） 核酸纳米药物开发及其生物效应
3） 基因治疗，mRNA疫苗及肿瘤免疫应用

1. L. Xue#, A. Thatte#, D. Mai, R. Haley, N. Gong, X. Han, N. Sheppard, C. June and M. Mitchell. Responsive Biomaterials: Optimizing Control of Cancer Immunotherapy. Nat. Rev. Mater., 2023, 9, 100 (#: Contributed equally).

2. L. Xue#, G. Zhao#, N. Gong#, X. Han, S. Shepherd, X. Xiong, J. Xu, K. Swingle, C. Warzecha, R. El-Mayta, J. Xu, J. Cui, Y. Shi, M. Alameh, K. Wang, L. Wang, D. Pochan, D. Weissman, A. Vaughan, J. Wilson and M. Mitchell. Combinatorial Design of Siloxane-Incorporated Lipid Nanoparticles Augment Tntracellular Processing for Tissue-Specific mRNA Therapeutic Delivery. Nat. Nanotechol., 2024, DOI: 10.1038/s41565-024-01747-6 (#: Contributed equally).

3. L. Xue, K. Swingle, and M. Mitchell. Small Structural Changes in Siloxane-Based Lipidoids Improve Tissue-Specific mRNA Delivery. Nat. Nanotechnol., 2024, DOI: 10.1038/s41565-024-01748-5.

4. L. Xue, A. Hamiton, G. Zhao, R. El-Mayta, X. Han, N. Gong, X. Xiong, J. Xu, C. Figueroa-Espada, S. Shepherd, A. Mukalel, M. Alameh, J. Cui, K. Wang, A. Vaughan, D. Weissman and M. Mitchell. High-Throughput Barcoding of Nanoparticles Identifies Cationic, Degradable Lipid-Like Materials for mRNA Delivery to the Lungs in Female Preclinical Models. Nat. Commun., 2024, 15, 1884.

5. L. Xue, X. Xiong, G. Zhao, W. Molina-Arocho, R. Palanki, Z. Xiao, X. Han, I. Yoon, C. Figueroa-Espada, J. Xu, N. Gong, Q. Shi, Q. Chen, M. Alameh, A. Vaughan, M. Haldar, K. Wang, D. Weissman and M. Mitchell. Multiarm-Assisted Design of Dendron-Like Degradable Ionizable Lipids Facilitate Systemic mRNA Delivery to the Spleen. J. Am. Chem. Soc., 2025, DOI: 10.1021/jacs.4c10265.

6. L. Xue#, N. Gong#, S. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M. Padilla, J. Qin, Y. Shi, M. Alameh, D. Pochan, K. Wang, F. Long, D. Weissman and M. Mitchell. Rational Design of Bisphosphate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J. Am. Chem. Soc., 2022, 144, 9926-9937 (#: Contributed equally).

7. L. Xue, X. Xiong, B. Krishnan, F. Puza, S. Wang, Y. Zheng and J. Cui. Light-Regulated Growth from Dynamic Swollen Substrates for Making Rough Surfaces. Nat. Commun., 2020, 11, 963.

8. N. Gong#, X. Han#, L. Xue#, R. EI-Mayta, A. Metzloff, M. Billingsley, A. Hamilton and M. Mitchell. In Situ PEGylation of CAR T Cells Alleviates Cytokine Release Syndrome and Neurotoxicity. Nat. Mater., 2023, 22, 1571 (#: Contributed equally).

9. G. Zhao#, L. Xue#, A. Weiner, N. Gong, S. Adams-Tzivelekidis, J. Wong, M. Gentile, A. Nottingham, M. Basil, S. Lin, T. Niethamer, J. Diamond, C. Bermudez, E. Cantu, X. Han, Y. Cao, M. Alameh, D. Weissman, E. Morrisey, M. Mitchell and A. Vaughan. TGFβR2 Signaling Coordinates Pulmonary Vascular Repair After Viral Injury. Sci. Transl. Med., 2024, 16, eadg6229 (#: Contributed equally).

10. G. Zhao#, L. Xue#, H. Geisler, J. Xu, X. Li, M. Mitchell and A. Vaughan. Precision Treatment of Viral Pneumonia through Macrophage-Targeted Lipid Nanoparticle Delivery. Proc. Natl. Acad. Sci. U.S.A. (PNAS), 2024, 121, e2314747121 (#: Contributed equally).

11. X. Han#, M. Alameh#, N. Gong#, L. Xue#, M. Ghattas, G. Bojja, J. Xu, G. Zhao, C. Warzecha, M. Padilla, R. Rl-Mayta, Y. Xu, A. Vaughan, J. Wilson, D. Weissman and M. Mitchell. Fast and Facile Synthesis of Amidine-Incorporated Degradable Lipids for Versatile mRNA Delivery In Vivo. Nat. Chem., 2024, 16, 1687-1697 (#: Contributed equally).

1. 2024年国家级青年人才项目（海外）

2. 2024年BWF BioInterface Rising Star Award，美国生物材料学会