工作经历：
2025.02 至今 南京大学医学院 准聘副教授
2022.10 – 2025.01 美国加州大学戴维斯分校（UC Davis）医学院药理系 助理项目科学家
2017.09 – 2022.09 美国加州大学戴维斯分校（UC Davis）医学院药理系 博士后
2017.03 – 2017.09 英国曼彻斯特大学 物理与天文学院 访问学者

教育背景：
2013.01 – 2017.03 英国曼彻斯特大学 物理与天文学院 博士研究生
2010.09 – 2012.08 哈尔滨工业大学 机电学院 硕士研究生
2006.08 – 2010.08 哈尔滨工业大学 机电学院 工学学士

科研方向：
1） 计算医学
2） 心脏数字孪生
3） 心血管疾病的个性化诊疗
4） 心脏电生理与生物力耦合

1. American Heart Association Career Development Award: Integrative human-based assay for multi-hit pharmacology: targeting ion channels and inflammasome in atrial fibrillation (24CDA1258695); total cost: $231,000. Role: PI. 2024 – 2027

2. NIH R01: Multiomic and Functional Analysis of PVC-Driven Idiopathic VF Predicts New Druggable Targets (R01 HL169328), total cost: $3,929,174. Role: Co-I (50% personal effort) MPIs: Eckhardt, L. and Grandi, E. 2023 – 2027

3. NIH R01: Functional Microdomains in the Heart's Pacemaker: A New Dimension of Cardiac Remodeling (R01 HL141214) total cost: $3,098,088. Role: Co-I (5% personal effort) PI: Glukhov, A. 2023 – 2028

4. American Heart Association Postdoctoral Fellowship (20POST35120462), $131,356; Role: PI. Jan 2020 – Dec 2021

1. Zhang X, Wu Y, Smith C, Louch WE, Morotti S, Dobrev D, Grandi E#, Ni H#. Enhanced Ca2+-Driven Arrhythmias in Female Patients with Atrial Fibrillation: Insights from Computational Modeling. bioRxiv. 2024. doi:10.1101/2024.03.04.583217 (Accepted in JACC-CEP, Received Editorial Comment from Dr T Hund, DOI: 10.1016/j.jacep.2024.08.019).

2. W Xiang*, L Li*, M Qin*, L Li, H Yu1, F Wang, S Ni, A Shen4, H Lu, H Ni#, Y Wang#. Diminished Nuclear-localized β-adrenergic signaling activates YAP to promote kidney fibrosis in diabetic nephropathy. (Accepted in British Journal of Pharmacology, 2024)

3. CE.R. Smith#, H Ni, E Grandi#. Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation. (Invited review article for Annual Review of Physiology, accepted)

4. L Reilly, M Josvai, M Kalluri, CL. Anderson, H Ni, KM. Orland, D Lang, AV. Glukhov, E Grandi, and L. Eckhardt. Starting at the end to get back to the beginning: a proof-of-concept study to identify cellular arhythmic features of Idiopathic Ventricular Fibrillation from patient-derived iPSC-cardiomyocytes (Accepted in JACC-CEP, 2024)

5. Hellgren KT, Ni H, Morotti S, Grandi E. Predictive male-to-female translation of cardiac electrophysiological response to drugs. JACC: Clinical Electrophysiology. 2023:9(12), 2642-2648 (Highlighted with an editorial)

6. Ni H, S Morotti, Zhang X, Dobrev D, Grandi E. Integrative human atrial modeling unravels interactive PKA and CaMKII signaling as key determinant of atrial arrhythmogenesis. Cardiovascular Research. 2023; 119 (13), 2294-2311. 10.1093/cvr/cvad118 (Editor’s Choice)

7. Bartolucci C, Ni H#. Calcium-directed feedback control of the sinoatrial node robustness. Biophysical Journal, 2023:122 (9), 1571-1573 http://doi.org/10.1016/j.bpj.2023.03.040

8. X. Zhang, H. Ni, S. Morotti, D. Sato, WE. Louch, AG. Edwards, E. Grandi. Mechanisms of spontaneous Ca2+ release‐mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse‐axial tubule variation. The Journal of Physiology. 2022. doi.org/10.1113/JP283363 (highlighted in journal editorial comments)

9. X. Zhang, C.E.R. Smith, S. Morotti, A.G. Edwards, D. Sato, W.E. Louch, H. Ni, E. Grandi. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II. Ca2+ -handling protein variation. The Journal of Physiology, 16 Sep 2022, DOI: 10.1113/jp283602 (highlighted in journal editorial comments)

10. Y Wang, M Zhao, B Xu, S Bahriz, C Zhu, A Jovanovic, H Ni, A Jacobi, N Kaludercic, F Di Lisa, J Shih, N Paolocci, Y K. Xiang. X. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 Jul 17;117(1):37.

11. Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Ripplinger C, Bers D, Edwards A, Grandi E. Quantitative cross-species translators of cardiac myocyte electrophysiology: model training, experimental validation, and applications. Science Advances 7(47):eabg0927 (F1000 recommendation)

12. Iseppe AF, Ni H, Zhu S, Zhang X, Coppini R, Yang P-C, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. 2021. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clinical Pharmacology & Therapeutics 110:380–391. doi:10.1002/cpt.2240

13. Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocytes and tissues reveal synergy of multi-atrial-predominant K+-current block in atrial fibrillation. British Journal of Pharmacology. 2020;177:4497–4515. doi: 10.1111/bph.15198

14. Z. Li, G.R. Mirams, T. Yoshinaga, B.J. Ridder, X. Han, J.E. Chen, N.L. Stockbridge, T.A. Wisialowski, B. Damiano, S. Severi, P. Morissette, P.R. Kowey, M. Holbrook, G. Smith, R.L. Rasmusson, M. Liu, Z. Song, Z. Qu, D.J. Leishman, J. Steidl‐Nichols, B. Rodriguez, A. Bueno‐Orovio, X. Zhou, E. Passini, A.G. Edwards, S. Morotti, H. Ni, E. Grandi, C.E. Clancy, J. Vandenberg, A. Hill, M. Nakamura, T. Singer, L. Polonchuk, A. Greiter‐Wilke, K. Wang, S. Nave, A. Fullerton, E.A. Sobie, M. Paci, F.M. Tshinanu, D.G. Strauss, General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy, Clinical Pharmacology & Therapeutics. 107 (2020) 102–111. https://doi.org/10.1002/cpt.1647.

15. Ni H, Zhang H, Grandi E, Narayan SM, Giles WR. Transient outward K+ current can strongly modulate action potential duration and initiate alternans in the human atrium. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H527-H542. (Highlighted in a podcast discussion from AJP: https://ajpheart.podbean.com/e/k-channel-isoforms-regulate-human-atrial-arrhythmogenesis/)

16. Ni H, Morotti S, Grandi E. A Heart for Diversity: Simulating Variability in Cardiac Arrhythmia Research. Front Physiol. 2018;9:958.

17. Ni H, Whittaker DG, Wang W, Giles WR, Narayan SM, Zhang H. Synergistic Antiarrhythmic Effects in Human Atria with Combined Use of Sodium Blockers and Acacetin. Front Physiol. 2017;8:946.

18. Ni H, Adeniran I, Zhang H. In-silico investigations of the functional impact of KCNA5 mutations on atrial mechanical dynamics. J Mol Cell Cardiol. 2017 Oct;111:86-95.

19. Ni H*, Wang Y*, Crawford W, Zhang S, Cheng L, Zhang H, Lei M. Three-dimensional image reconstruction of distribution of Pnmt+ cell-derived cells in murine heart. Sci Data. 2017 Sep 26;4:170134. [*Co-first author]

20. Colman MA*, Ni H*, Liang B, Schmitt N, Zhang H. In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis. PLoS Comput Biol. 2017 Jun;13(6):e1005587. [*Co-first author]

21. Brocklehurst P*, Ni H*, Zhang H, Ye J. Electro-mechanical dynamics of spiral waves in a discrete 2D model of human atrial tissue. PLoS One. 2017;12(5):e0176607. [*Co-first author]

22. Chen M, Ni H, Wang Z, Jiang Y. Research on the modelling of burr formation process in micro-ball end milling operation on Ti–6Al–4V. The International Journal of Advanced Manufacturing Technology. 2012;62(9-12):901–12.

A complete List of publications can also be accessed from: PubMed: https://www.ncbi.nlm.nih.gov/myncbi/1-Wgd3_98Zmwjq/bibliography/public/

Google Scholar: https://scholar.google.com/citations?user=sdywTqEAAAAJ&hl=en

• American Heart Association Career Development Award 2024-2027

• American Heart Association BCVS New Investigator Travel Grant 2024

• UC Davis Academic Federation Faculty Research Travel Grant 2024

• Biophysical Society Travel Award 2023

• UC Davis Academic Federation Faculty Research Travel Grant 2022

• 2022 UC Davis Award for Excellence in Postdoctoral Research Nomination 2022

• UC Davis Postdoctoral Scholars Association Travel Award 2021

• American Heart Association Postdoctoral Fellowship 2020-2021

• Chinese Government Award for Outstanding Self-Financed Students Abroad 2017

• Virtual Physiological Human Institute Travel Award 2014

• Dean’s Award (Faculty PhD Studentship), University of Manchester 2013

• Chiang Chen Foundation (Hong Kong) Scholarship (top 3%) 2010-2012

• 美国心脏协会（AHA）研究基金会评委员会成员（2020，2021，2022）

• Circulation

• Guest Associate Editor: Frontiers in Physiology

• Review Editor: Frontiers in Physiology – Cardiac Electrophysiology

• Review Editor: Frontiers in Physiology – Computational Physiology and Medicine

• IEEE Transactions on Medical Imaging

• International Journal of Cardiology

• International Journal of Computer Assisted Radiology and Surgery

• Frontiers in Physiology

• F1000Research

• American Journal of Physiology – Heart and Circulatory Physiology

• Medical & Biological Engineering & Computing

• Computers in Biology and Medicine

• Journal of Molecular and Cellular Cardiology

• Philosophical Transactions of the Royal Society A

• Frontiers in Cell and Developmental Biology

• PLoS One

• PLoS Computational Biology

• The Journal of Physiology

• Physiological Reports

• JACC: Clinical Electrophysiology

• Communications Biology

• Biophysical Journal

• Cardiovascular Drugs and Therapy

• Clinical Pharmacology & Therapeutics

• Scientific Reports

• iScience